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KMID : 0381219860180040348
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Journal of RIMSK
1986 Volume.18 No. 4 p.348 ~ p.352
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The Cardiovascular Changes of Sodium Nitroprusside, Nitroglycerin and
Induced Hemorrhage
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Abstract
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Induced hypotensive technique is used in order to improve operating conditions of extensive major operation.
The technique has developed into combination of physical, physiological and phamacological controls. Sodium nitroprusside(SNP) is used frequently as pharmacological control, but it has same disadvantages. Recently, a interest has developed in hypotensive action of nitroglycerin (NTG).
Hemodynamic studies were made in 6 Korean dogs which was received sodium nitroprusside or nitroglycerin and induced hemorrhage. The measurements were taken after mean
arterial pressure was reduced to 60 mmHg(30%) with SNP, NTG and induced hemorrhage groups and then compared with control group.
The results are as follows.
1) Central venous pressure, pulmonary capillary wedge pressure, cardiac output and systemic vascular resistance were not observed significant changes in all groups.
2) Pulse pressure in induced hemorrhage was significantly decreased in comparison with control groups.
These results suggest that pulse pressure is more sensitive parameter in induced hemorrhage. And then the characteristic changes of each groups will be observed by further decrease of mean arterial pressure more than 30%.
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